|Optical coherence tomography (OCT) is a high resolution imaging technique that can take 3D images of tissue. OCT is similar to ultrasound in that it measures the echo of light reflected from tissue, however it uses interferometry to determine the extremely small time-of-flight of light reflected from a few millimeters depth.
OCT technology can be used to form high resolution depth scans of biological specimens, such as the retina (see figure) or arterial all, and plays a key role in early detection of anomalies in vision, heart conditions, etc. The spatial resolution enables an accurate (up to 4-10 micron) imaging of the biological layers up to few millimeters deep. However due to aberrations induced by the imaging optics or the specimen, the lateral resolution is limited.
In this project we develop adaptive optics technology that can compensate for the wavefront aberrations and yield high resolution images both axially and laterally, but at the same time result into a cost-effective hardware design. This leads to a multi-criteria optimization problem where from the beginning the presence of a feedback loop is taken into consideration in the design of the imaging instrument.