People Education Research Industrial Agenda  
 
Current Research Archive Publications PhD theses Software      

 
Previous      Up      Next

Game-Theoretical and Optimal Control Methods in Systems Biology

Project members:  K. Stankova, A. Abate
 
Keywords:  Systems biology, Game theory, Predator-prey problems, Optimization and algorithms for control, Hybrid systems , Multi-agent systems
 
Sponsored by:  NWO
 
Systems Biology is an interdisciplinary field that pursues data-driven, model-based studies of biological organisms and functions. The use of quantitative models is intended to be tightly coupled with biological knowledge. Within this project, we pursue the development of quantitative models for the so-called predator-prey problems to study and understand competition and cooperation among organisms interacting within a resource-constrained environment.

The theory of evolutionary games provides the basis for understanding the interaction and the dynamics between populations of such organisms. The solution of these games over sets of possible strategies is related to specific optimality conditions for the populations under study. An important question is whether such strategies are evolutionary stable, i.e. unbeatable under given initial conditions.

We intend to develop game-theoretical models for predator-prey systems, describing the intra-seasonal (continuous) and inter-seasonal (discrete) dynamics. Collaboration with colleagues in biology is a key element in the derivation of such models. Individual models together with pre-specified metrics of optimality of the interacting species will form hybrid games of the Nash or Stackelberg type. Firstly, by solving such games we will find optimal strategies for the involved populations. Secondly, we will investigate for which parameter domains these strategies are evolutionary stable.

Another goal of this project is construction of new, ad-hoc optimality conditions over the considered game-theoretical problems. The use of new metrics for optimality will allow to establish a framework to understand survival properties, competitive strategies, as well as cooperative behaviors among interacting populations of organisms.

Previous      Up      Next

Back to top

Last modified: 9 July 2012, 11:25 UTC
Search   Site map