Dynamical models for the quantitative understanding of the Drosophila melanogaster development

Project members:dr.ir. A. Abate (Alessandro)
Keywords:Discrete-event systems

This line of research, which can be classified within the Systems Biology area, investigates the development of dynamical models over data obtained from wet lab experiments, to answer questions on the developmental biology of the Drosophila melanogaster (the known fruit fly).

The work is conducted in collaborations with researchers from the Medical School at Stanford University, and from the Department of EECS at the University of California, Berkeley.

We are in particular looking at two directions:
1. Planar Cell Polarity: Epithelial cells are polarized, producing patterned arrays within the epithelium (referred to as Planar Cell Polarity). We are working to understand the signaling events and cellular responses that produce this polarization.
2. Segmental Groove Formation: In the fly embryo, specific bands of cells in the mesoderm fold to form segmental grooves. We are studying how these cells and how they execute this response.

© Copyright Delft Center for Systems and Control, Delft University of Technology, 2017.